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| Wellbutrin Sr 100 mg / 150 mg |
Brand Name: Wellbutrin Sr
Generic Name: Bupron SR, Nosmoq
Manufacturer: GlaxoSmithKline
Diseases: Depression, Smoking
Dosage: 100mg / 150mg
Wellbutrin Sr Bupropion belongs to the family of medications known as antidepressants. It is used to treat depression. It works by affecting the balance of chemicals that occur naturally in the brain.
For the treatment of depression, the full effects of the medication may not be seen until after several weeks of treatment.
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. As well, some forms of this medication may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
What Is Wellbutrin SR?
Wellbutrin SR® (bupropion SR) is a prescription medicine used for the treatment of depression (also known as major depression or clinical depression). It is a sustained-release (long-acting) version of Wellbutrin® (bupropion hydrochloride).
Who Makes It?
Wellbutrin SR is manufactured by GlaxoSmithKline. Generic versions are made by several manufacturers.
How Does Wellbutrin SR Work?
Wellbutrin SR is a norepinephrine and
dopamine reuptake inhibitor, or NDRI for short.
NDRIs affect specific chemicals within the brain known as norepinephrine and dopamine. These are two of several chemicals used to send messages from one nerve cell to another.
As a message travels down a nerve, it causes the end of the cell to release norepinephrine or dopamine. The chemical then enters the gap between the first nerve cell and the one next to it. When enough norepinephrine or dopamine reaches the second nerve cell, it activates receptors on the cell and the message continues on its way. The first cell then quickly absorbs any norepinephrine or dopamine that remains in the gap between the cells. This is called "reuptake."
Normally, this process works without any problems. However, when the levels of dopamine and norepinephrine become unbalanced, it can cause a variety of conditions, including depression and seasonal affective disorder (SAD). Wellbutrin SR helps to block the reuptake of norepinephrine and dopamine so that more remains in the space between the brain's nerve cells. This gives the chemicals a better chance of activating the receptors on the next nerve cell.
Currently, the only NDRI antidepressants approved for use are medications containing bupropion. Wellbutrin SR is a sustained-release version of bupropion, usually taken twice a day. Bupropion also comes in several other forms, including:
- Wellbutrin® (bupropion hydrochloride), a short-acting version, taken three or four times a day
- Budeprion SR®, a generic version of Wellbutrin SR
- Wellbutrin XL®, Forfivo™ XL, or Budeprion XL® (bupropion XL), a long-acting version, taken once a day
- Aplenzin™ (bupropion hydrobromide), taken once a day
- Zyban® (bupropion SR) or Buproban®, a sustained-release version used for smoking cessation, taken twice a day.
- you are allergic to any ingredient in Wellbutrin SR Sustained-Release Tablets
- you are taking any other medicine that contains bupropion
- you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)
- you are suddenly stopping the use of alcohol or sedatives (eg, benzodiazepines) after long-term use
- you are taking or have taken linezolid, methylene blue, or a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days
General Wellbutrin SR Dosing Information
Some considerations for people taking Wellbutrin SR include:
- It usually takes four weeks (or longer) to feel the full beneficial effects of Wellbutrin SR. Therefore, try not to be discouraged if Wellbutrin SR does not work right away for you.
- When taking Wellbutrin SR twice daily, you should make sure that there is at least eight hours in between doses.
- It does not matter if you take Wellbutrin SR with or without food. If Wellbutrin SR bothers your stomach, try taking it with food.
- Be sure to swallow Wellbutrin SR tablets whole. The tablets should not be cut, broken, chewed, or crushed.
- Wellbutrin SR should be taken at the same times each day to maintain even levels of the drug in your blood.
- For Wellbutrin SR to work properly, you have to take it as prescribed. Wellbutrin SR will not work if you take it in a way other than how your healthcare provider has prescribed.
- If you are unsure about anything related to your dosage or Wellbutrin SR dosing in general, please talk with your doctor, nurse, or pharmacist. Do not stop taking Wellbutrin SR without first discussing it with your healthcare provider.
The recommended starting Wellbutrin SR dose for depression is Wellbutrin SR 150 mg once daily in the morning. As soon as the fourth day, your healthcare provider may increase your dose to Wellbutrin SR 150 mg twice daily. To help avoid seizures, each individual dose should not exceed 200 mg, and you should not take more than 400 mg total per day. Also, your healthcare provider should increase your dose slowly.
For people with liver problems (such as liver failure or cirrhosis), the maximum Wellbutrin SR dose is Wellbutrin SR 100 mg once daily or 150 mg every other day.
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Important safety information:
- Wellbutrin SR Sustained-Release Tablets may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Wellbutrin SR Sustained-Release Tablets with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Wellbutrin SR Sustained-Release Tablets; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Wellbutrin SR Sustained-Release Tablets may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you use a lot of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Wellbutrin SR Sustained-Release Tablets.
- If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.
- Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Wellbutrin SR Sustained-Release Tablets without first checking with your doctor. They may increase your risk of seizures.
- The risk of seizures may be greater if you take Wellbutrin SR Sustained-Release Tablets in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Wellbutrin SR Sustained-Release Tablets for longer than prescribed without checking with your doctor.
- Children, teenagers, and young adults who take Wellbutrin SR Sustained-Release Tablets may be at increased risk of suicidal thoughts or actions. Watch all patients who take Wellbutrin SR Sustained-Release Tablets closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood; anxious, restless, or irritable behavior; panic attacks; or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
- If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.
- Wellbutrin SR Sustained-Release Tablets contains the same ingredients as Zyban, a medicine used to help stop smoking, and Aplenzin, another medication used to treat depression. Do not take Wellbutrin SR Sustained-Release Tablets if you are also taking Zyban or Aplenzin. Discuss any questions or concerns with your doctor.
- Wellbutrin SR Sustained-Release Tablets may interfere with certain lab tests, including urine screenings for amphetamines. Be sure your doctor and lab personnel know you are taking Wellbutrin SR Sustained-Release Tablets.
- Use Wellbutrin SR Sustained-Release Tablets with caution in the ELDERLY; they may be more sensitive to its effects.
- Wellbutrin SR Sustained-Release Tablets should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Wellbutrin SR Sustained-Release Tablets while you are pregnant. Wellbutrin SR Sustained-Release Tablets are found in breast milk. Do not breast-feed while taking Wellbutrin SR Sustained-Release Tablets.
Pros
Low chance of sexual side effects, unless you consider making you hornier with or without premature/spontaneous orgasms sexual side effects. None of the weight gain associated with SSRIs & SNRIs. Often a very effective and relatively fast-acting antidepressant, as dopamine and norepinephrine reuptake inhibition are frequently part of, if not the answer for a lot of people.
Cons
Wellbutrin can be used recreationally, so it can be abused. It has to be avoided by anyone with an eating disorder or other addictive behaviors. The abuse potential is a serious problem, as Wellbutrin is one of the few modern antidepressants that can kill you if you take too much.
Wellbutrin SR Side Effects: An Introduction
As with any medicine, side effects are possible with Wellbutrin SR® (bupropion SR). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it well. If Wellbutrin SR side effects occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
Common Side Effects of Wellbutrin SR
Wellbutrin SR has been studied thoroughly in
clinical trials. In these studies,
the side effects that occur in a group of people taking the drug are documented and are then compared to side effects that occur in another group of people not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
In these studies, some of the most common side effects of Wellbutrin SR included:
- Headaches -- in up to 26 percent of people
- Dry mouth -- up to 24 percent of people (see Wellbutrin SR and Dry Mouth)
- Weight loss -- up to 19 percent of people (see Wellbutrin SR and Weight Loss)
- Nausea -- up to 18 percent of people
- Insomnia -- up to 16 percent of people (see Wellbutrin SR and Insomnia)
- Dizziness -- up to 11 percent of people
- A sore throat -- up to 11 percent of people
- Constipation -- up to 10 percent of people
- Infections -- up to 9 percent of people
- Abdominal pain (or stomach pain) -- up to 9 percent of people
- Agitation -- up to 9 percent of people
- Diarrhea -- up to 7 percent of people
- The sensation of a rapidly or forcefully beating heart (palpitations) -- up to 6 percent of people
- Muscle pain -- up to 6 percent of people
- Anxiety -- up to 6 percent of people
- Shakiness (tremors) -- up to 6 percent of people
- Increased sweating -- up to 6 percent of people
- Ringing in the ears (tinnitus) -- up to 6 percent of people.
- A loss of appetite
- Frequent urination, bladder infections, or other urinary problems
- Weakness
- Flushing (redness of the skin, especially the face)
- Migraine headaches
- Joint pain or arthritis
- Taste changes
- Hot flashes
- Drowsiness
- Memory loss
- Sinus infections
- A fever
- Vomiting
- Trouble swallowing
- Muscle twitching
- Unpleasant sensations, such as burning or tingling (paresthesias)
- Coughing
- Vaginal bleeding.
In US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
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